The cerebellar cognitive affective syndrome. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.īuckner RL. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the “language” functional boundaries in the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries.
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If we hold a note down, and move to another note while it is held, the LFO will simply continue. This means the LFO will only retrigger if we lift our finger off of a note and strike a new note. Have a look in the Modulation area, and we can see how the LFO's range changes.īelow the waveform, we can see that the LFO is set to 'Legato'. When we turn this parameter off, the sound will now pan in both a positive and negative direction, panning through the full stereo field. When lit, this means the LFO is moving in only a positive direction, in the case of panning, we would be getting center to right. Now check out the little blue '+' symbol above the arrows we were just clicking. To change the LFO waveshape, simply click on the up and down arrows next to the LFO wave. Head over to the LFO section, and make sure LFO 1 is selected. To get out of the Mod Matrix, simply click the magnifying glass next to 'Mod Matrix Zoom' again. Now we have the LFO back to its full range of motion. try altering the 'Depth' parameter of the Wheel in the Mod Matrix. We can hear now that the panning isn't as extreme as it was before. To have the LFO depth completely zeroed out when the ModWheel is down, simply turn the target parameter slider to the left until it reads '0'. and when we turn the wheel up, the panning is accentuated. We can still hear the LFO altering our panning, but less. To create second order modulation where the ModWheel is controlling the depth of the LFO, assign 'Wheel' as a source, and 'LFO1 depth' as the target. Second Order Modulation is simply a modulation source controlling the parameters of another modulation source. This is called 'Second Order Modulation'. What would be good is to use something like the ModWheel on our controller to control how much the LFO is going to affect panning. This could be annoying, and make us a little seasick after a while of listening. Now we have LFO 1 controlling panning, but all the time. When clicked, the magnifying glass will reveal the following screen: The Modulation Matrix can be found by heading over to the Modulation section of the Omnishpere Edit window and selecting the magnifying glass. Step 1 - Get to Know the Modulation Matrix For instance, if we have a sine wave LFO assigned to control a pan knob, we'll hear the sound move between the left and right channel according to the speed and shape of the LFO assigned.įor this article-which I could easily stretch into a book, but will hold back-we are going to explore some of the more advanced LFO and Envelope types, and then assign them in the Mod Matrix! Mind melting fun. Modulation is when we assign an envelope, LFO, controller, or other modulation source to control a parameter of a synthesizer. Omnisphere has some serious modulation going on.Ī quick recap on modulation. Innocently enough, they click on the little symbol, and the revelation within turns their minds to a gloopy jelly. Then some people look a little closer and see that next to the Envelopes, Modulation and LFO areas, a curious little magnifying glass beckons. 'Oh how quaint, I can route the ModWheel to and LFO's depth' they say. 'Oh, I have an Amp, Filter, and Mod envelope' they say. Some people are happy with Omnisphere's top-level user interface. The interface is uncluttered and easy to navigate compared to other synths, but under the surface. On the surface, Omnisphere seems like another wonderful sounding software instrument with a great library of sounds, great effects, and a sweet synth engine. The Mini-Browser uses only the left-most area of the interface, making the controls still accessible-convenient for editing sounds while browsing.Omnisphere is the dreamchild of Spectrasonics and the wonderful Eric Persing. The Full Browser uses the entire Omnisphere user interface, which allows for more refined searches and results. There are two types of Browsers in Omnisphere: the Full Browser and the Mini-Browser. For example, when the Multi Browser is open, only Multis will be accessible in the Browser. Multis, Patches, and Soundsources have their own Browsers with the same layout and identical functions, but they interact with different parts of the library. The more you understand about how the Browser works, the better you will be able to utilize and enjoy the Omnisphere sound library. Using categories, searchable attributes called Tags, as well as Projects and Sharing, the Browsers add a powerful and important feature to the workflow in Omnisphere. The Browsers in Omnisphere were designed to provide an intuitive and convenient way to quickly find exactly what you need from a library containing many thousands of sounds. 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